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Fish Shellfish Immunol 49:427435 Stec DE, Gordon DM, Hipp JA, Hong S, Mitchell ZL, Franco NR et al (2019) Loss of hepatic PPAR promotes inflammation and serum hyperlipidemia in diet-induced obesity

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As mechanisms to dispose of both hydrogen peroxide and lipid hydroperoxides are essential to life, this indicates that in contrast to the multiple metabolic pathways that can be utilized to dispose of hydrogen peroxide, pathways for the disposal of lipid hydroperoxides are limited

Published 2023 May 31

In the realm of clinical trials, statins such as simvastatin (MS-STAT2 trial, NCT03896217) for MS and atorvastatin (NCT00356473, NCT04177173) for RA have demonstrated the potential to reduce disease activity and slow progression (241, 242)